Role of Progesterone Receptors In Breast Cancer
نویسندگان
چکیده
منابع مشابه
The Role of Toll-Like Receptors in Breast Cancer
Breast cancer is highly prevalent worldwide. Treatment of this disease is a major global public health problem; therefore, numerous studies have explored new molecular profile helping for breast cancer therapy. Different risk factors are attributed to breast cancer; however, chronic inflammation and immune regulation are highly essential. Various molecules impact this context, including toll-li...
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Background & objective: Breast cancer is the leading cause of cancer related death in females. Sphingosine kinase 1 (SPHK1) and its product sphingosine-1-phosphate (S1P) are the essential key regulator molecules in breast cancer through their ability to promote cell proliferation, angiogenesis, cell proliferation, and lymphagiogenesis. SPHK1 i...
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More than 60% of all breast neoplasias are ductal carcinomas expressing estrogen (ER) and progesterone receptors (PR). By contrast, most of the spontaneous, chemically or mouse mammary tumor virus induced tumors, as well as tumors arising in genetically modified mice do not express hormone receptors. We developed a model of breast cancer in which the administration of medroxyprogesterone acetat...
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in ER-positive tumors would indicate that the tumor is capa ble of synthesizing at least 1 end product under estrogen regulation and may therefore be endocrine responsive (8). Although the hypothesis assumes that PGR levels in breast tumors, like those in the uterus, are under estrogen control, this priming effect has never been demonstrated. In this paper we show that PGR in the DMBA-induced m...
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The nucleoside adenosine is present within cells and body fluids of all living organisms and its production, both intra- and extracellularly, is tightly coupled to energy consumption resulting in increased level of extracellular adenosine. The physiological effects of adenosine are mediated through four pharmacologically and biochemically distinct adenosine receptors (AR), i.e. A1, A2A, A2B and...
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ژورنال
عنوان ژورنال: CA: A Cancer Journal for Clinicians
سال: 1986
ISSN: 0007-9235
DOI: 10.3322/canjclin.36.5.302